N-Methyl-tert-butylamine → 5-[(7-{(2E)-4-[tert-Butyl(methyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-yl)amino]-2,3-dichlorophenol

Participants

Reaction Steps

The compound was synthesized in analogy to Example 147 from 2,3-dichloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 69A (85 mg, 0.21 mmol), (2E)-4-bromobut-2-enoic acid (52 mg, 0.32 mmol) and tert-butyl methylamine (29 mg, 0.34 mmol) to yield 18 mg (16%).

Provenance & Evidence