HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(3,4-dichlorophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(3,4-Dichlorophenyl)piperazine | HCID 93601 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal | HCID 86639930 | — |
| Product | 1-(3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propyl)-4-(3,4-dichlorophenyl)piperazine | HCID 68560032 | — |
Reaction Steps
199 mg (93%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-3-propyl-1H-pyrazol-5-yl)propanal (100 mg, 0.450 mmol), 1-(3,4-dichlorophenyl)piperazine (104 mg, 0.450 mmol), DIPEA (0.118 mL, 0.675 mmol) and NaBH(OAc)3 (286 mg, 1.350 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372844B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-f07d6300edc14483a6873c64f2bab1f1 |
| Source note | uspto-grants-2013_02 |