Methyl iodide → 1-[4-chloro-3-(trifluoromethyl)phenyl]-S-methylisothiourea hydroiodide
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH2:11])=[S:10])=[CH:4][C:3]=1[C:12]([F:15])([F:14])[F:13].[CH3:16][I:17]>CO>[IH:17].[CH3:16][S:10][C:9](=[NH:11])[NH:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([C:12]([F:15])([F:13])[F:14])[CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4-Chloro-3-trifluoromethyl-phenylthiourea (5.0 g, 19.63 mmol) was dissolved in ca. 80 mL of anhydrous MeOH and methyl iodide (2.93 g, 20.61 mmol) was added via a syringe. The reaction mixture was refluxed for 12 hours. Then it was cooled down to ambient temperature and solvent was removed in vacuo to give colorless oil (7.85 g), which was taken to the next step without further purifications.
Workup
- temperatureThe reaction mixture was refluxed for 12 hours
- customsolvent was removed in vacuo
Sources & evidence
- ORD record
- ord-1f9659046d19427a899901f7e2b09927
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08372971B2
Reaction notes
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