Isobutyric Acid → Tetramethylammonium Isobutyrate

HRID 388530

Reaction equation

HRID 388530 reaction equation
[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[CH3:3].[OH-].[CH3:8][N+:9]([CH3:12])([CH3:11])[CH3:10]>>[C:1]([O-:6])(=[O:5])[CH:2]([CH3:4])[CH3:3].[CH3:8][N+:9]([CH3:12])([CH3:11])[CH3:10]

Participants

3

Reactant 2

HCID 6590Isobutyric AcidHCID 60966Tetramethylammonium hydroxide

Product 1

HCID 21900158Tetramethylammonium Isobutyrate

Procedure

To a 20 L, round bottom flask was added isobutyric acid (1300 mL, 14 mol), and an aqueous solution of 25% tetramethylammonium hydroxide (5 L, 14 mol). The water was removed under reduced pressure, and azeotroped with toluene (2×2 L) to leave the product (1b) as an amber liquid, which was used without further purification.

Workup

  1. customThe water was removed under reduced pressure
  2. customazeotroped with toluene (2×2 L)

Sources & evidence

ORD record
ord-02433c0517344fa890fe40f57c38bd4f
Source dataset
uspto-grants-2013_02
Patent number
US08377956B2

Linked notes

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