Isobutyric Acid → Tetramethylammonium Isobutyrate

HRID 389360

Reaction equation

HRID 389360 reaction equation
[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[CH3:3].[OH-].[CH3:8][N+:9]([CH3:12])([CH3:11])[CH3:10]>>[C:1]([O-:6])(=[O:5])[CH:2]([CH3:4])[CH3:3].[CH3:8][N+:9]([CH3:12])([CH3:11])[CH3:10]

Participants

3

Reactant 2

HCID 6590Isobutyric AcidHCID 60966Tetramethylammonium hydroxide

Product 1

HCID 21900158Tetramethylammonium Isobutyrate

Procedure

To a 20 L round bottom flask was added isobutyric acid (1300 mL, 14 mol), and an aqueous solution of 25% tetramethylammonium hydroxide (5 L, 14 mol). The water was removed under reduced pressure, and azeotroped with toluene (2×2 L) to leave the product (15) as an amber liquid, which was used without further purification.

Workup

  1. customThe water was removed under reduced pressure
  2. customazeotroped with toluene (2×2 L)

Sources & evidence

ORD record
ord-bcedb9fad9344fc7bb078fa31b0ae44b
Source dataset
uspto-grants-2013_02
Patent number
US08378137B2

Linked notes

Loading…