Benzyl mercaptan → 1-Benzylsulfanyl-3-bromo-2-trifluoromethyl-benzene

HRID 389654

Reaction equation

HRID 389654 reaction equation
[C:1]1([CH2:7][SH:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12](F)[C:11]=1[C:17]([F:20])([F:19])[F:18]>>[CH2:7]([S:8][C:12]1[CH:13]=[CH:14][CH:15]=[C:10]([Br:9])[C:11]=1[C:17]([F:18])([F:20])[F:19])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 7509Benzyl mercaptanHCID 27733452-Bromo-6-fluorobenzotrifluoride

Product 1

HCID 671552591-Benzylsulfanyl-3-bromo-2-trifluoromethyl-benzene

Procedure

Phenyl-methanethiol (4.g g, 37.0 mmol) was treated with commercially available 1-bromo-3-fluoro-2-trifluoromethyl-benzene (10.0 g, 41.1 mmol) in close analogy to the procedure described in step 5.3). The crude product (10.5 g) after workup was used as such in the next reaction step without purification by chromatography.

Workup

  1. customsuch in the next reaction step
  2. customwithout purification by chromatography

Sources & evidence

ORD record
ord-e82cb9c16d524ad382d59b2d011bdb18
Source dataset
uspto-grants-2013_02
Patent number
US08378092B2

Linked notes

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