Water → 2-Hydroxy-1-(3-methylphenyl)ethan-1-one

HRID 389896

Reaction equation

HRID 389896 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)=[O:4].[OH2:12]>C(#N)C>[OH:12][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 962WaterHCID 100361292-Bromo-1-(3-methylphenyl)ethan-1-one

Product 1

HCID 183729052-Hydroxy-1-(3-methylphenyl)ethan-1-one

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 2-bromo-1-(3-methylphenyl)ethanone (1 g) in acetonitrile (2.5 mL) and water (13 mL) is treated under microwave irradiation (125° C., 50 min). The same experiment is repeated three times. All the vials are collected, extracted with DCM, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

Workup

  1. customAll the vials are collected
  2. extractionextracted with DCM
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-53b1fb3a11334045a8e1fdc82626b016
Source dataset
uspto-grants-2013_02
Patent number
US08383608B2

Linked notes

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