HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → [(2R)-7-(Trifluoromethylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl 4-methylbenzenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | o-Toluenesulfonyl chloride | HCID 8623 | — |
| Reactant | [7-(Trifluoromethylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methanol | HCID 66878696 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | [(2R)-7-(Trifluoromethylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl 4-methylbenzenesulfonate | HCID 86652938 | — |
Reaction Steps
Preparation according to Preparation 22 using [7-(trifluoromethylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methanol (0.75 g, 2.5 mmol), toluenesulfonyl chloride (0.72 g, 3.8 mmol), TEA (0.42 ml, 3 mmol) and 4-DMAP (0.37 g, 3.0 mmol) in DCM (40 ml), stirred for 18 h. Yield 0.28 g. MS m/z (rel. intensity, 70 eV) 452 (M+, bp), 383 (41), 280 (82), 211 (80), 91 (84).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524766B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-f2081859b3ba465aae8f87e4b3bf260f |
| Source note | uspto-grants-2013_09 |