Ammonia → HCID 44546164, compound

HRID 390440

Reaction equation

HRID 390440 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[Br:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]#[CH:19])=[CH:14][CH:13]=1.N>>[Br:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[CH:19]=2)=[CH:14][CH:13]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 136603Benzene, 1-bromo-4-ethynyl-HCID 53404818N-Hydroxy-3-pyridinecarboximidoyl chloride

Product 1

HCID 44546164HCID 44546164, compound

Procedure

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-bromo-4-ethynylbenzene (Alfa Aesar, 80 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.66 (dd, J=7.7, 5.0 Hz, 1H), 7.75-8.01 (m, 5H), 8.36 (dt, J=8.0, 1.9 Hz, 1H), 8.76 (dd, J=4.8, 1.6 Hz, 1H), 9.14 (s, 1H) ppm; MS (DCI/NH3) m/z 303 (M+H)+, 301 (M+H)+.

Sources & evidence

ORD record
ord-6e7a7de5826d45b684348dc3331ab287
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Linked notes

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