Ammonia → HCID 44546230, compound

HRID 390451

Reaction equation

HRID 390451 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[C:11]([C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[C:16]#[N:17])#[CH:12].N>>[N:6]1[CH:7]=[CH:8][CH:9]=[C:4]([C:3]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=3)[C:16]#[N:17])[O:1][N:2]=2)[CH:5]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 120889643-EthynylbenzonitrileHCID 53404818N-Hydroxy-3-pyridinecarboximidoyl chloride

Product 1

HCID 44546230HCID 44546230, compound

Procedure

The titled compound was prepared according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and the product of Example 19A (64 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) 87.53 (s, 1H), 7.61 (ddd, J=8.1, 5.0, 0.8 Hz, 1H), 7.75 (t, J=7.8 Hz, 1H), 7.88 (dt, J=7.7, 1.4 Hz, 1H), 8.23 (dt, J=8.1, 1.4 Hz, 1H), 8.31 (t, J=1.7 Hz, 1H), 8.38 (dt, J=8.1, 1.9 Hz, 1H), 8.68 (dd, J=5.1, 1.7 Hz, 1H), 9.10 (d, J=2.0 Hz, 1H) ppm; MS (DCI/NH3) m/z 248 (M+H)+.

Sources & evidence

ORD record
ord-b1b41d70655f425087946eb5c818ffb9
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Linked notes

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