Ammonia → HCID 44546415, compound

HRID 390477

Reaction equation

HRID 390477 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:5]=[N:6][CH:7]=[N:8][CH:9]=1.[C:11]([C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[C:16]#[N:17])#[CH:12].N>>[N:6]1[CH:5]=[C:4]([C:3]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=3)[C:16]#[N:17])[O:1][N:2]=2)[CH:9]=[N:8][CH:7]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 120889643-EthynylbenzonitrileHCID 86636847N-Hydroxypyrimidine-5-carbimidoyl chloride

Product 1

HCID 44546415HCID 44546415, compound

Procedure

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 44B (79 mg, 0.5 mmol) and the product of Example 19A (64 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.83 (t, J=7.8 Hz, 1H), 7.94 (s, 1H), 8.04 (dt, J=7.8, 1.4 Hz, 1H), 8.25 (dt, J=8.1, 1.4 Hz, 1H), 8.42 (t, J=1.5 Hz, 1H), 9.32 (s, 2H), 9.36 (s, 1H) ppm; MS (DCI/NH3) m/z 249 (M+H)+.

Sources & evidence

ORD record
ord-4288092cf4314dc1bfe38a122b8748c8
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Linked notes

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