HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(3-(Pyrazin-2-yl)isoxazol-5-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Ethynylbenzonitrile | HCID 12088964 | — |
| Reactant | N-Hydroxypyrazine-2-carbimidoyl chloride | HCID 136395910 | — |
| Product | 3-(3-(Pyrazin-2-yl)isoxazol-5-yl)benzonitrile | HCID 44545616 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 83D (79 mg, 0.5 mmol) and the product of Example 19A (64 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.59 (s, 1H), 7.75 (t, J=8.1 Hz, 1H), 7.88 (dt, J=8.0, 1.4, 1.2 Hz, 1H), 8.21-8.30 (m, 1H), 8.31-8.37 (m, 1H), 8.71 (d, J=2.7 Hz, 1H), 8.77 (dd, J=2.5, 1.5 Hz, 1H), 9.31 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 249 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-39ba24d52ad3487ba3e3c80508a3c58c |
| Source note | uspto-grants-2013_02 |