Methyl iodide → (NZ)-N-[3-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]-3-methylimidazol-3-ium-1-carboxamide iodide

HRID 390699

Reaction equation

HRID 390699 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][S:10]/[C:9]/2=[N:13]\[C:14]([N:16]2[CH:20]=[CH:19][N:18]=[CH:17]2)=[O:15])=[CH:4][CH:3]=1.[I:21][CH3:22]>C(#N)C>[I-:21].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:12][CH2:11][S:10]/[C:9]/2=[N:13]\[C:14]([N:16]2[CH:20]=[CH:19][N+:18]([CH3:22])=[CH:17]2)=[O:15])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 87449094HCID 87449094, compound

Product 1

HCID 87447829(NZ)-N-[3-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]-3-methylimidazol-3-ium-1-carboxamide iodide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

N-[(2Z)-3-(4-Chlorophenyl)-1,3-thiazolidin-2-ylidene]-1H-imidazole-1-carboxamide (320 mg, 1.043 mmol, Example 25A) was suspended in dry acetonitrile (5 mL), and then iodomethane (0.325 mL, 5.22 mmol) was added. The mixture stirred at room temperature. After four days, the solvent was evaporated to give the title product.

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-9fa71b9d1bd841759cde32862025345d
Source dataset
uspto-grants-2013_02
Patent number
US08383657B2

Linked notes

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