Sodium Chloride → Epinephrine

HRID 39111

Reaction equation

HRID 39111 reaction equation
[CH3:1][NH:2][CH2:3][C@H:4]([OH:13])[C:5]1[CH:6]=[CH:7][C:8]([OH:12])=[C:9]([OH:11])[CH:10]=1.Cl.[Cl-].[Na+]>O>[CH3:1][NH:2][CH2:3][C@H:4]([OH:13])[C:5]1[CH:6]=[CH:7][C:8]([OH:12])=[C:9]([OH:11])[CH:10]=1

Participants

4

Reactant 2

HCID 5234Sodium ChlorideHCID 441411(-)-Epinephrine hydrochloride

Product 1

HCID 5816Epinephrine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.2 g of epinephrine HCl, 10.0 g of polyvinylpyrrolidone K 12 prepared as in Example 7 and 7.5 g of sodium chloride were dissolved in 998.0 g of water for injections which had been boiled and cooled under nitrogen. The solution was sterilized by filtration through a 0.22 μm filter and dispensed under nitrogen into 1 ml ampoules.

Workup

  1. temperaturecooled under nitrogen
  2. filtrationThe solution was sterilized by filtration through a 0.22 μm
  3. filtrationfilter

Sources & evidence

ORD record
ord-a03c66ed758f4aabbd732eea919a75e3
Source dataset
uspto-grants-2013_09
Patent number
US08524827B2

Linked notes

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