5-(2-Phenyleth-1-Ynyl)Nicotinic Acid → HCID 24952432, compound

HRID 391511

Reaction equation

HRID 391511 reaction equation
[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[N:11][CH:12]=[C:13]([CH:17]=2)[C:14]([OH:16])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][S@@:19]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[NH:21])=[O:20]>>[CH3:18][S@@:19](=[O:20])([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[N:21][C:14](=[O:16])[C:13]1[CH:17]=[C:9]([C:8]#[C:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:10]=[N:11][CH:12]=1

Participants

3

Reactant 2

HCID 27792365-(2-Phenyleth-1-Ynyl)Nicotinic AcidHCID 25036286[S(R)]-S-Methyl-S-phenylsulfoximine

Product 1

HCID 24952432HCID 24952432, compoundYield 25%

Procedure

In a manner similar to that described in Example 423, 5-(2-phenyleth-1-ynyl)nicotinic acid and (R)-(−)-S-methyl-S-phenylsulfoximine were reacted to give the title compound as a white foam (54 mg, 25%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-7a315afa3c2647d79eb8c56dfb2b5326
Source dataset
uspto-grants-2013_02
Patent number
US08383825B2

Linked notes

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