Methyl iodide → HCID 22663158, compound

Reaction equation

[CH2:1]([NH:8][C:9]1[CH:10]=[C:11]([C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:27][CH3:28])=[C:22]([O:25][CH3:26])[CH:23]=3)[N:18]=[C:17]([NH:29][CH3:30])[N:16]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:31]I>>[CH2:1]([N:8]([C:9]1[CH:10]=[C:11]([C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:27][CH3:28])=[C:22]([O:25][CH3:26])[CH:23]=3)[N:18]=[C:17]([NH:29][CH3:30])[N:16]=2)[CH:12]=[CH:13][CH:14]=1)[CH3:31])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 22663144HCID 22663144, compound

Product 1

HCID 22663158HCID 22663158, compoundYield 33.8%

Procedure

Starting from 100 mg of 4-(3-benzylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline obtained in Example 38 and 71.0 mg of methyl iodide, 35.0 mg of the title compound was obtained as a pale yellow oil in the same manner as in Example 38.

Sources & evidence

ORD record: ord-ecbea7fe94a94c6b95821af69bfa1d0a
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06800644B2

Reaction notes

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