Ammonia → 6-Amino-3-methoxy-2-pyrazinecarboxamide
Reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8](OC)=[O:9])[C:5]([O:12][CH3:13])=[N:4][CH:3]=1.[NH3:14]>CO>[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH2:14])=[O:9])[C:5]([O:12][CH3:13])=[N:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In 70 mL of methanol was dissolved 3.5 g of methyl 6-amino-3-methoxy-2-pyrazinecarboxylate. After introducing gaseous ammonia into the solution to prepare a saturated solution, and the solution was stirred at room temperature for 14 hours. By removing the solvent from the reaction mixture under reduced pressure, 3.1 g of 6-amino-3-methoxy-2-pyrazinecarboxamide was obtained as a solid product.
Workup
- customto prepare a saturated solution
- customBy removing the solvent from the reaction mixture under reduced pressure
Sources & evidence
- ORD record
- ord-654326750ebb43cc8c006ba7c4e18125
- Source dataset
- uspto-grants-2004_10
- Patent number
- US06800629B2
Reaction notes
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