HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-(3-Hydroxy-3-methyl)butyl-4-fluorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 6-fluoro-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-one | HCID 11063293 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | HCID 178505374 | HCID 178505374 | — |
| Product | 2-(3-Hydroxy-3-methyl)butyl-4-fluorophenol | HCID 22663744 | — |
Reaction Steps
A solution of 6-fluoro-2,2-dimethyl-chroman-4-one (EP 193493; 1 equiv.) in ethanol (0.24 M) was treated with copper chromite (0.6 equiv.). The reaction was heated to 200° C. for 6 hours at 3000 psi of hydrogen gas. The reaction was filtered and concentrated to a solid. The crude material was recrystallized form hot hexanes to give the title compound. MS found 198 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06800651B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-53bacbbe0cda493bb6cdbae6e52d0284 |
| Source note | uspto-grants-2004_10 |