5-Methyl-1,3,4-oxadiazol-2-amine → 9H-Xanthene-9-carboxylic acid (5-methyl-[1,3,4]oxadiazol-2-yl)-amide

HRID 392727

Reaction equation

HRID 392727 reaction equation
[CH3:1][C:2]1[O:6][C:5]([NH2:7])=[N:4][N:3]=1.[CH:8]1[C:21]2[CH:20]([C:22](Cl)=[O:23])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[O:13][C:12]=2[CH:11]=[CH:10][CH:9]=1>>[CH3:1][C:2]1[O:6][C:5]([NH:7][C:22]([CH:20]2[C:21]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[O:13][C:14]3[C:19]2=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:23])=[N:4][N:3]=1

Participants

3

Reactant 2

HCID 20602505-Methyl-1,3,4-oxadiazol-2-amineHCID 27608929H-xanthene-9-carbonyl chloride

Product 1

HCID 865854659H-Xanthene-9-carboxylic acid (5-methyl-[1,3,4]oxadiazol-2-yl)-amide

Procedure

The title compound, white solid, m.p. 261-263° C. and MS: m/e=307.1 (M+) was prepared in accordance with the general method of example 44a from 5-methyl[1,3,4]oxadiazol-2-ylamine and 9-xanthene-carboxylic acid chloride. The 5-methyl[1,3,4]oxadiazol-2-ylamine, white solid, MS: m/e=99 (M+) used in the above reaction was prepared in accordance with the general method of example 48b from acetic acid hydrazide and cyanogen bromide.

Sources & evidence

ORD record
ord-892a3b3739ef438c8d554e0050eba24e
Source dataset
uspto-grants-2004_10
Patent number
US06803381B1

Linked notes

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