1-O-alpha-D-Glucopyranosyl-D-mannitol → Trehalose

HRID 393492

Reaction equation

HRID 393492 reaction equation
[CH2:1]([OH:23])[C@H:2]1[O:7][C@H:6]([O:8][CH2:9][C@@H:10]([OH:19])[C@@H:11]([OH:18])[C@H:12]([OH:17])[C@H:13]([OH:16])[CH2:14][OH:15])[C@H:5]([OH:20])[C@@H:4]([OH:21])[C@@H:3]1[OH:22]>O>[CH2:1]([OH:23])[C@H:2]1[O:7][C@H:6]([O:8][C@H:9]2[O:16][C@H:13]([CH2:14][OH:15])[C@@H:12]([OH:17])[C@H:11]([OH:18])[C@H:10]2[OH:19])[C@H:5]([OH:20])[C@@H:4]([OH:21])[C@@H:3]1[OH:22]

Participants

3

Reactant 1

HCID 887351-O-alpha-D-Glucopyranosyl-D-mannitol

Product 1

HCID 7427Trehalose

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
125 °C

Procedure

Ninety-five parts by weight of high-purity crystalline trehalose hydrate and 18 parts by weight of palatinit were placed in a dissolving tank, and admixed with and dissolved by heating in 63 parts by weight of water. The solution was placed in a concentrator, concentrated to boil down by heating to 125° C. under reduced pressure, continued concentrating by heating under reduced pressure while keeping the temperature until reaching to a moisture content of about 1.0%. Similarly as in Example A-1, the concentrate was subjected to an extruder for forming, cooled to ambient temperature to obtain a short-rod thermoplastic shaped-body of trehalose, about 2 mm in diameter and about 4 mm in length. Since the product was a colorless, transparent or translucent, and substantially amorphous shaped-body having thermoplasticity and satisfactory storage-stability under indoor circumstances, it can be arbitrarily reheated to a temperature of about 90° C. to about 160° C. to impart it free-flowing ability, then transformed or processed into a shaped-body with an appropriate form with or without using other substances having different functions. The product can be also used arbitrarily for preparing a paste containing trehalose by dissolving in a relatively-small amount of hot water, and the resulting paste can be used intact in an amorphous form or used as a powdered base after crystallization of trehalose.

Workup

  1. dissolutiondissolved
  2. concentrationconcentrated
  3. concentrationcontinued concentrating
  4. temperatureby heating under reduced pressure
  5. customfor forming
  6. temperaturecooled to ambient temperature

Sources & evidence

ORD record
ord-e2d0f268a5e4473baed019330ac142fc
Source dataset
uspto-grants-2004_10
Patent number
US06808651B1

Linked notes

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