HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Chloro-6,7-dimethoxyquinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 6,7-Dimethoxy-4-hydroxyquinoline | HCID 459611 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Chloro-6,7-dimethoxyquinoline hydrochloride | HCID 22646543 | — |
Reaction Steps
A suspension of 6,7-dimethoxy-1,4-dihydroquinolin-4-one (3 g, 14 mmol), (J. Chem. Soc. 1940, 1209), in thionyl chloride (60 ml) and DMF (0.3 ml) was heated at reflux for 3 hours. Excess thionyl chloride was removed by evaporation and the residue azeotroped with toluene and washed with ether to give 4-chloro-6,7-dimethoxyquinoline hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06809097B1 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-d6a9307ea24f421bade5e071b6ab5a54 |
| Source note | uspto-grants-2004_10 |