HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 39362Generated: October 25, 2026
Water → N-(5-(pyrazin-2-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)acetamide
https://huagongshe.com/reaction/39362
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chloropyrazine | HCID 73277 | — |
| Reactant | N-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)acetamide | HCID 28274565 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-(5-(pyrazin-2-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)acetamide | HCID 46873663 | 9.7% |
Reaction Steps
As shown in step 10-iv of Scheme 10, to a solution of 50 mg of Compound 1035 in 3 mL of NMP was added 100 mg of 2-chloro pyrazine. The reaction mixture was warmed to 250° C. for 10 minutes under microwave irradiation. The reaction was poured into water (10 mL) and the crude product collected by filtration. The crude solid was purified by silica gel chromatography (CH2Cl2 to EtOH) to provide N-(5-(pyrazin-2-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)acetamide (Compound 1, 6.8 mg): ESMS (M+H) 276.16.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08524906B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-33e117da437743818d6eadef14513599 |
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| Source note | uspto-grants-2013_09 |
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