Aluminium lithium hydride → 3-(2-Phenyl-thiazol-4-yl)-propan-1-ol

HRID 394276

Reaction equation

HRID 394276 reaction equation
C([O:3][C:4](=O)[CH2:5][CH2:6][C:7]1[N:8]=[C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[S:10][CH:11]=1)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[C:12]1([C:9]2[S:10][CH:11]=[C:7]([CH2:6][CH2:5][CH2:4][OH:3])[N:8]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 686166683-(2-Phenyl-thiazol-4-yl)-propionic acid ethyl ester

Product 1

HCID 226474953-(2-Phenyl-thiazol-4-yl)-propan-1-olYield 76%

Procedure

In analogy of the procedure described in example 12 b], 0.44 g (1.68 mmol) of 3-(2-phenyl-thiazol-4-yl)-propionic acid ethyl ester was reacted with lithium aluminium hydride, yielding 0.28 g of 3-(2-phenyl-thiazol-4-yl)-propan-1-ol as colorless liquid (75.8% of theory).

Sources & evidence

ORD record
ord-07277705a0cd4d4985dca79089eb6c04
Source dataset
uspto-grants-2004_10
Patent number
US06809110B2

Linked notes

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