3-Iodophthalic anhydride → HCID 18178020, compound

HRID 394958

Reaction equation

HRID 394958 reaction equation
[I:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([O:7][C:8](=[O:9])[C:3]=12)=[O:6].[CH3:13][CH:14]([NH2:19])[CH2:15][CH2:16][S:17][CH3:18]>C(#N)C>[I:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]([C:5]([OH:7])=[O:6])[C:3]=1[C:8]([NH:19][CH:14]([CH3:13])[CH2:15][CH2:16][S:17][CH3:18])=[O:9]

Participants

4

Reactant 2

HCID 2820713-Iodophthalic anhydrideHCID 229794044-(Methylsulfanyl)butan-2-amine

Product 1

HCID 18178020HCID 18178020, compoundYield 89.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

To a suspension of 2.74 g of 3-iodophthalic anhydride in 8 ml of acetonitrile cooled with ice was slowly added dropwise a solution of 1.19 g of 1-methyl-3-methylthiopropylamine in 3 ml of acetonitrile. After completion of the dropping, a reaction was carried out at room temperature for 3 hours with stirring. After completion of the reaction, the deposited crystal was collected by filtration and washed with a small quantity of acetonitrile. Thus, 3.5 g of the objective compound was obtained.

Workup

  1. temperaturecooled with ice
  2. customAfter completion of the reaction
  3. filtrationthe deposited crystal was collected by filtration
  4. washwashed with a small quantity of acetonitrile

Sources & evidence

ORD record
ord-44769b3aa80b4d76933f15c5015bfff4
Source dataset
uspto-grants-2003_08
Patent number
US06603044B1

Linked notes

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