Ethyl 2-chloroisonicotinate → Ethyl 2-(4-chloro-3,5-dimethoxyphenyl)isonicotinate

Reaction equation

[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5](B(O)O)=[CH:4][C:3]=1[O:13][CH3:14].Cl[C:16]1[CH:17]=[C:18]([CH:24]=[CH:25][N:26]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:16]2[CH:17]=[C:18]([CH:24]=[CH:25][N:26]=2)[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:4][C:3]=1[O:13][CH3:14]

Participants

Reactant 2

HCID 2762942Ethyl 2-chloroisonicotinate

HCID 22485557(4-Chloro-3,5-dimethoxyphenyl)boronic acid

Product 1

HCID 22557799Ethyl 2-(4-chloro-3,5-dimethoxyphenyl)isonicotinate

Procedure

4-Chloro-3,5-dimethoxyphenylboronic acid (7.45 g) and ethyl 2-chloroisonicotinate (6.39 g) were condensedn in the same manner as described in Preparation Example 1 to give the title compound.

Workup

customas described in Preparation Example 1

Sources & evidence

ORD record: ord-df9a1b14f15a4ddeaca9487ad6b9af68
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06605620B1

Reaction notes

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