3,4-Difluoroaniline → 1-Boc-4-[(3,4-difluorophenyl)amino]-piperidine

HRID 395545

Reaction equation

HRID 395545 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:15][C:16]1[CH:17]=[C:18]([CH:20]=[CH:21][C:22]=1[F:23])[NH2:19]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:19][C:18]2[CH:20]=[CH:21][C:22]([F:23])=[C:16]([F:15])[CH:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 774693,4-DifluoroanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 225580331-Boc-4-[(3,4-difluorophenyl)amino]-piperidine

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and 3,4-difluoroaniline (3.09 g) was treated in the same manner as described in Preparation Example 37 to give light brown prism crystal of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-67250492626c45bca1f434266b92ba8f
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Linked notes

Loading…