2-amino-N-(4-methoxyphenyl)benzamide → 2-[(2-Butoxy-4-methoxybenzoyl)amino]-N-(4-methoxyphenyl)benzamide

HRID 395766Notes

Reaction equation

HRID 395766 reaction equation
[CH2:1]([O:5][C:6]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=O)[CH2:2][CH2:3][CH3:4].[NH2:17][C:18]1[CH:34]=[CH:33][CH:32]=[CH:31][C:19]=1[C:20]([NH:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)=[O:21]>>[CH2:1]([O:5][C:6]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:7]=1[C:8]([NH:17][C:18]1[CH:34]=[CH:33][CH:32]=[CH:31][C:19]=1[C:20]([NH:22][C:23]1[CH:24]=[CH:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=1)=[O:21])=[O:10])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 4788202-amino-N-(4-methoxyphenyl)benzamideHCID 134507642-Butoxy-4-methoxybenzoic acid

Product 1

HCID 181745942-[(2-Butoxy-4-methoxybenzoyl)amino]-N-(4-methoxyphenyl)benzamideYield 25.2%

Procedure

Using the procedure described in Example 102, Part A, 2-butoxy-4-methoxybenzoic acid (0.54 mmol) and 2-amino-N-(4-methoxyphenyl)benzamide (0.54 mmol) yielded 61 mg (25%) of the title compound.

Sources & evidence

ORD record
ord-72fe10891037467b885298298edf2ba6
Source dataset
uspto-grants-2003_08
Patent number
US06605626B2

Reaction notes

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