(4-Methylphenyl)hydrazine → 3-[(2-fluoro-4-iodophenyl)amino]-N'-(4-methylphenyl)isonicotinohydrazide

HRID 39589

Reaction equation

HRID 39589 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[CH3:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][NH2:27])=[CH:22][CH:21]=1>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:27][NH:26][C:23]1[CH:24]=[CH:25][C:20]([CH3:19])=[CH:21][CH:22]=1)=[O:14]

Participants

3

Reactant 2

HCID 10875(4-Methylphenyl)hydrazineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 115327343-[(2-fluoro-4-iodophenyl)amino]-N'-(4-methylphenyl)isonicotinohydrazide

Procedure

3-[(2-fluoro-4-iodophenyl)amino]-N′-(4-methylphenyl)isonicotinohydrazide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.4 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.6 mmol of 4-methyl-phenylhydrazine. LC/MS [5.07 min; 463 (M+1)]

Workup

  1. customLC/MS [5.07 min; 463 (M+1)]

Sources & evidence

ORD record
ord-6e7af9cdae7c4d0385dc58252ea993b0
Source dataset
uspto-grants-2013_09
Patent number
US08524911B2

Linked notes

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