1-(4-Chloro-pyridin-2-yl)-ethanone → 2-Acetyl-4-propylpyridine

Reaction equation

[CH2:1]([C:4]1C=CN=C(C#N)C=1)[CH2:2]C.[C:12]([C:15]1[CH:20]=[C:19](Cl)[CH:18]=[CH:17][N:16]=1)(=[O:14])[CH3:13]>>[C:12]([C:15]1[CH:20]=[C:19]([CH2:2][CH2:1][CH3:4])[CH:18]=[CH:17][N:16]=1)(=[O:14])[CH3:13]

Participants

Reactant 2

HCID 130119861-(4-Chloro-pyridin-2-yl)-ethanone

HCID 230032234-Propylpicolinonitrile

Product 1

HCID 230034442-Acetyl-4-propylpyridine

Procedure

The title compound was prepared from 4-propyl-2-pyridinecarbonitrile according to the procedure for preparing 2-acetyl-4-chloropyridine described in Example 33.

Sources & evidence

ORD record: ord-b214eb8979fe4434ab8450b0a2b37e5a
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06608070B1

Reaction notes

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