[6-Chloro-2-(4-methylpyridine-2-Carbonyl)-1H-indol-3-yl]acetic Acid → Methyl[5-tert-butyl-2-(4-methylpyridine-2-carbonyl)-1h-indol-3-yl]acetate
Reaction equation
[C:1]([C:5]1[CH:6]=[CH:7][C:8]([NH:17]S(C2C=CC(C)=CC=2)(=O)=O)=[C:9]([CH:16]=1)/[CH:10]=[CH:11]/[C:12]([O:14][CH3:15])=[O:13])([CH3:4])([CH3:3])[CH3:2].ClC1C=C2C(C(CC(O)=O)=[C:34]([C:38]([C:40]3[CH:45]=[C:44]([CH3:46])[CH:43]=[CH:42][N:41]=3)=[O:39])N2)=CC=1>>[CH3:15][O:14][C:12](=[O:13])[CH2:11][C:10]1[C:9]2[C:8](=[CH:7][CH:6]=[C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])[CH:16]=2)[NH:17][C:34]=1[C:38]([C:40]1[CH:45]=[C:44]([CH3:46])[CH:43]=[CH:42][N:41]=1)=[O:39]Participants
3
Procedure
The compound was prepared according to the procedure described in Example of 57 from methyl trans-5-tert-butyl-2-(p-toluenesulfonylamino)cinnamate (step 2) and 2-bromoacetyl-4-methylpyridine hydrobromide (Preparation is described in step 2 of Example 31).
Workup
- customThe compound was prepared