2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one → 2-Bromo-1-(4-chloro-3-fluorophenyl)ethanone

Reaction equation

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[C:6]([F:11])[CH:5]=1)(=[O:3])[CH3:2].FC(F)(F)OC1C=CC(C(=O)C[Br:21])=CC=1>>[Cl:10][C:7]1[CH:8]=[CH:9][C:4]([C:1](=[O:3])[CH2:2][Br:21])=[CH:5][C:6]=1[F:11]

Participants

Reactant 2

HCID 27786912-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one

HCID 38220774'-Chloro-3'-fluoroacetophenone

Product 1

HCID 230032952-Bromo-1-(4-chloro-3-fluorophenyl)ethanone

Procedure

The title compound was prepared from 4-acetyl-1-chloro-2-fluorobenzene according to the procedure for preparing 4-(trifluoromethoxy)phenacyl bromide described in Example 189.

Sources & evidence

ORD record: ord-86f99c8b0d224e58a066098b6d6b2277
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06608070B1

Reaction notes

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