1-(1,3-Thiazol-5-yl)ethan-1-one → 2-Bromo-1-(thiazol-5-yl)ethanone hydrobromide

Reaction equation

[C:1]([C:4]1[S:8][CH:7]=[N:6][CH:5]=1)(=[O:3])[CH3:2].[BrH:9].[Br:10]CC(C1C=C(C)C=CN=1)=O>>[BrH:10].[Br:9][CH2:2][C:1]([C:4]1[S:8][CH:7]=[N:6][CH:5]=1)=[O:3]

Participants

Reactant 2

HCID 140423291-(1,3-Thiazol-5-yl)ethan-1-one

HCID 230036032-Bromoacetyl4-methylpyridine hydrobromide

Product 1

HCID 230035582-Bromo-1-(thiazol-5-yl)ethanone hydrobromide

Procedure

* 5-bromoacetylthiazole hydrobromide was prepared from 5-acetylthiazole according to the procedure for preparing 2-bromoacetyl-4-methylpyridine hydrobromide described in step 2 of Example 31.

Sources & evidence

ORD record: ord-64edddb875d942759324e44cf49c99b8
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06608070B1

Reaction notes

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