HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl 2-(methylamino)-2-phenylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methanamine, hydrochloride (1:1) | HCID 11637 | — |
| Reactant | Benzeneacetic acid, alpha-bromo-, methyl ester | HCID 137806 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-(methylamino)-2-phenylacetate | HCID 13852358 | 71.2% |
Reaction Steps
In this example a mixture containing 30.7 g of methyl bromo-phenylacetate, 36.2 g of methyl ammonium chloride (i.e. CH3NH3Cl); 3.0 g of benzyltriethylammonium chloride and 67.5 g of sodium bicarbonate in about 300 ml of methylene chloride (and about 25 ml of water) was warmed to refluxed and refluxed for about 18 hours. The mixture was then cooled and washed three times with water, dried over magnesium sulfate and concentrated by vacuum evaporation affording 17.1 g of the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04723031 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-c156814239954cc794d18661347d1e7d |
| Source note | uspto-grants-1988_02 |