HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrimidine-2-carboxylic acid → 1-(1H-benzo[d]imidazol-2-ylsulfonyl)-N'2-[(2-pyrimidinylcarbonyl)oxy]-2-piperidinecarboximidamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrimidine-2-carboxylic acid | HCID 12626245 | — |
| Reactant | 1-(1H-benzimidazol-2-ylsulfonyl)-N'-hydroxypiperidine-2-carboximidamide | HCID 59085911 | — |
| Product | 1-(1H-benzo[d]imidazol-2-ylsulfonyl)-N'2-[(2-pyrimidinylcarbonyl)oxy]-2-piperidinecarboximidamide | HCID 72511979 | — |
Reaction Steps
The title compound was prepared by a similar method to Preparation 20 from (Z)-1-(1H-benzo[d]imidazol-2-ylsulfonyl)-N′2-hydroxy-2-piperidinecarboximidamide [see Preparation 19] and pyrimidine-2-carboxylic acid (see Chem. Ind. (London), 1954, 786) to afford 1-(1H-benzo[d]imidazol-2-ylsulfonyl)-N′2-[(2-pyrimidinylcarbonyl)oxy]-2-piperidinecarboximidamide as a gum. The title compound was used directly in Example 65.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610707B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-b78570b2820e42c6a35112e4006ce9ad |
| Source note | uspto-grants-2003_08 |