Reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10]([N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1/[C:19](=[N:21]/[OH:22])/[NH2:20])(=[O:12])=[O:11].[N:23]1[CH:28]=[CH:27][CH:26]=[N:25][C:24]=1[C:29](O)=[O:30]>>[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10]([N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[C:19](=[N:21][O:22][C:29]([C:24]1[N:25]=[CH:26][CH:27]=[CH:28][N:23]=1)=[O:30])[NH2:20])(=[O:11])=[O:12]Participants
3
Procedure
The title compound was prepared by a similar method to Preparation 20 from (Z)-1-(1H-benzo[d]imidazol-2-ylsulfonyl)-N′2-hydroxy-2-piperidinecarboximidamide [see Preparation 19] and pyrimidine-2-carboxylic acid (see Chem. Ind. (London), 1954, 786) to afford 1-(1H-benzo[d]imidazol-2-ylsulfonyl)-N′2-[(2-pyrimidinylcarbonyl)oxy]-2-piperidinecarboximidamide as a gum. The title compound was used directly in Example 65.
Sources & evidence
- ORD record
- ord-b78570b2820e42c6a35112e4006ce9ad
- Source dataset
- uspto-grants-2003_08
- Patent number
- US06610707B1
Linked notes
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