HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Naproxen | HCID 156391 | — |
| Solvent | Isobutanol | HCID 6560 | — |
| Product | isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate | HCID 54469957 | — |
Reaction Steps
A solution of 300 mg of (S)-2-(6-methoxy-2-naphthyl)propionic acid in 5 ml of isobutyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue is purified by chromatography using an alumina substrate to yield isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04723033 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-8b2fe1a99b9b4f7d9bf65ad29d804e7a |
| Source note | uspto-grants-1988_02 |