Dimethyl Sulfoxide → (2r,3r,4s,5s)-2-{6-(1-Ethyl-propylamino)-2-[2-(1-methyl-1h-imidazol-4-yl)-ethylamino]-purin-9-yl}-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-tetrahydro-furan-3,4-diol formate

Participants

Reaction Conditions

Reaction Steps

Intermediate 11 (0.069 g, 0.163 mmol) and 2-(1-methyl-1H-imidazol-4-yl)ethylamine (0.102 g, 0.815 mmol) were dissolved in DMSO (0.03 ml) and heated at 85-100° C. under nitrogen for 7 days, a further portion of 2-(1-methyl-1H-imidazol-4-yl)ethylamine (0.102 g, 0.815 mmol) was added after the first 5 days. The product was purified by Autoprep. HPLC to give the title compound after freeze drying as a beige solid (0.013 g). LC/MS system A Rt=3.32 min, m/z=512MH+.

Provenance & Evidence