Dimethyl Sulfoxide → HCID 70020694, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Intermediate 23 (0.075 g, 0.135 mmol), and 2-(1-methyl-1H-imidazol-4-yl)ethylamine (0.085 g, 0.677 mmol) in diisopropylethylamine (0.04 ml) and DMSO (0.04 ml), in a sealed vial (e.g. Reacti-vial™) was heated at 85° C. for 40 h. A further portion of 2-(1-methyl-1H-imidazol-4-yl)ethylamine (0.085 g, 0.677 mmol) was added after the first 20 h. Purification by Autoprep. HPLC afforded the title compound after freeze drying as a cream solid (0.037 g). LC/MS system B Rt=2.71 mins, m/z=651 MH+

Provenance & Evidence