Hydrogen chloride-ethyl acetate → Carbostyrilhydrochloride
Reaction equation
O1C2C=CC(CN(C3CCN(CC[N:28]4[C:37]5[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=5)[CH:31]=[CH:30][C:29]4=[O:38])CC3)C(=O)OC(C)(C)C)=CC=2OCC1.[ClH:39].C(OCC)(=O)C>>[ClH:39].[NH:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=[CH:30][C:29]1=[O:38]Participants
3
Procedure
To 0.13 g of tert-butyl (2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 10 mL of 4 mol/L hydrogen chloride/ethyl acetate solution was added, and left to stand at room temperature for 3 days. The solvent was removed under reduced pressure, 2-propanol was added to the residue obtained and the solvent was removed under reduced pressure. Ethyl acetate was added to the residue thus obtained and the resulting solid was filtered to afford 0.10 g of 1-(2-(4-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-quinolin-2(1H)one hydrochloride as a yellow solid.
Workup
- waitleft
- customThe solvent was removed under reduced pressure, 2-propanol