HCID 23000218, compound → HCID 23000253, compound
Reaction equation
[C:1]([N:4]([C:10]1[N:15]=[CH:14][CH:13]=CN=1)[CH2:5][CH2:6][CH2:7][C:8]#[CH:9])(=[O:3])[CH3:2]>[N+](C1C=CC=CC=1)([O-])=O>[C:1]([N:4]1[C:10]2[C:7](=[C:8]([CH3:9])[CH:13]=[CH:14][N:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2-(N-acetyl-N-pent-4-ynylamino)pyrimidine (3.49 g, 17.2 mmol) in nitrobenzene (35 mL) was heated under argon at 180° C. for 2 days. The reaction mixture was cooled and loaded directly onto a dry silica get column. The column was first eluted with methylene chloride to wash off the nitrobenzene and then was eluted with ether to give after evaporation in vacuo to give the title compound as a pale yellow solid:
Workup
- temperatureThe reaction mixture was cooled
- customget column
- washThe column was first eluted with methylene chloride
- washto wash off the nitrobenzene
- washwas eluted with ether
- customto give
- customafter evaporation in vacuo
Sources & evidence
- ORD record
- ord-4660dcf9e4ad498fa43053eaf3ddf8ee
- Source dataset
- uspto-grants-2003_08
- Patent number
- US06610692B1
Reaction notes
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