Propionyl chloride → N-(3-Piperidin-4-yl-1H-pyrrolo[3,2-b]pyridin-5-yl)-propionamide

HRID 398919

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[C:24](Cl)(=[O:27])[CH2:25][CH3:26]>>[C:24]([NH:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1)(=[O:27])[CH2:25][CH3:26]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 117268345-Amino-3-(1-tert-butoxycarbonylpiperidin-4-yl)pyrrolo[3,2-b]pyridine

Product 1

HCID 10945589N-(3-Piperidin-4-yl-1H-pyrrolo[3,2-b]pyridin-5-yl)-propionamide

Procedure

Beginning with 0.015 gm (0.047 mMol) 5-amino-3-(1-tert-butoxycarbonylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.005 mL (0.062 mMol) propionyl chloride, the title compound was prepared.

Sources & evidence

ORD record: ord-580e13026a8445fc945db7b47b97114b
Source dataset: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05817671

Linked notes

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