Isoindoline → HCID 10638841, compound

Reaction equation

Cl[CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([F:14])=[C:10]2[C:6]=1[CH2:7][C:8](=[O:15])[NH:9]2.[CH2:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][NH:17]1>>[CH2:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][N:17]1[CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([F:14])=[C:10]2[C:6]=1[CH2:7][C:8](=[O:15])[NH:9]2

Participants

Reactant 2

HCID 422478Isoindoline

HCID 10704607HCID 10704607, compound

Product 1

HCID 10638841HCID 10638841, compoundYield 75%

Procedure

4-(2-Chloroethoxy)-7-fluoro-1,3-dihydro-indol-2-one was reacted with isoindoline in the same manner described for intermediate 16 to afford the title compound in 75% yield as a thick oil. The fumarate salt was prepared in ethanol: mp 210°-212° C.

Sources & evidence

ORD record: ord-252cb9b7741d44db84ddf1af7599a548
Source dataset: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05817690

Reaction notes

Loading…