HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6-methoxyquinazolin-7-yl acetate → 7-Acetoxy-6-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6-methoxyquinazolin-7-yl acetate | HCID 22243885 | — |
| Reactant | 3-Methyl-4-(pyridin-2-ylmethoxy)aniline | HCID 23438288 | — |
| Product | 7-Acetoxy-6-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline | HCID 18967657 | 64% |
Reaction Steps
Using an analogous procedure to that described in Example 1 except that the reaction mixture was heated to reflux for 3 hours, 7-acetoxy-4-chloro-6-methoxyquinazoline was reacted with 5-amino-2-tolyl 2-pyridylmethyl ether to give 7-acetoxy-6-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline in 64% yield;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821246 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-2670b9d7cc724f1aac0441a748810cc1 |
| Source note | uspto-grants-1998_10 |