4-Chloro-7-methoxyquinazolin-6-yl acetate--hydrogen chloride (1/1) → 6-Acetoxy-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline

HRID 399489

Reaction equation

HRID 399489 reaction equation
Cl.[C:2]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH3:17])[N:12]=[CH:11][N:10]=[C:9]2Cl)(=[O:4])[CH3:3].[N:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH2:25][O:26][C:27]1[C:28]([CH3:34])=[CH:29][C:30]([NH2:33])=[CH:31][CH:32]=1>>[C:2]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH3:17])[N:12]=[CH:11][N:10]=[C:9]2[NH:33][C:30]1[CH:31]=[CH:32][C:27]([O:26][CH2:25][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][N:19]=2)=[C:28]([CH3:34])[CH:29]=1)(=[O:4])[CH3:3]

Participants

3

Reactant 2

HCID 220221594-Chloro-7-methoxyquinazolin-6-yl acetate--hydrogen chloride (1/1)HCID 234382883-Methyl-4-(pyridin-2-ylmethoxy)aniline

Product 1

HCID 189676446-Acetoxy-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazolineYield 60%

Procedure

Using an analogous procedure to that described in Example 1, 6-acetoxy-4-chloro-7-methoxyquinazoline, hydrochloride salt, was reacted with 5-amino-2-tolyl 2-pyridylmethyl ether to give 6-acetoxy-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline in 60% yield;

Sources & evidence

ORD record
ord-b3526fe5e063495b896cd4af83ece54b
Source dataset
uspto-grants-1998_10
Patent number
US05821246

Linked notes

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