1-Azabicyclo[2.2.2]octane-4-carbonitrile → Quinuclidin-4-ylmethanamine
Reaction equation
[C:1]([C:3]12[CH2:10][CH2:9][N:6]([CH2:7][CH2:8]1)[CH2:5][CH2:4]2)#[N:2]>C(Cl)Cl.CO>[NH2:2][CH2:1][C:3]12[CH2:10][CH2:9][N:6]([CH2:7][CH2:8]1)[CH2:5][CH2:4]2Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Colourless oil; Rf : 0.3 (trace of tailing; alumina; methylene chloride/methanol=7:3); Mass spectrum: M+=140; Prepared from 4-cyanoquinuclidine (see Example 3 of EP-A-0,213,337).
Sources & evidence
- ORD record
- ord-939eed98b7bf40c9a1e9354970f719ef
- Source dataset
- uspto-grants-1998_10
- Patent number
- US05821240
Reaction notes
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