Formic Acid → Methyl 3-formamidocinnamate
Reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[CH:5]=[CH:6][C:7]([O:9][CH3:10])=[O:8].[CH:14](O)=[O:15]>O>[CH:14]([NH:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[CH:5]=[CH:6][C:7]([O:9][CH3:10])=[O:8])=[O:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
193 g of methyl 3-aminocinnamate and 900 ml of formic acid were mixed and heated under reflux for 2 hours. The reaction solution was poured into water and the crystals (methyl 3-formamidocinnamate) obtained were collected by filtration. Yield: 127 g.
Workup
- temperatureheated
- temperatureunder reflux for 2 hours
Sources & evidence
- ORD record
- ord-544208453dae4717be0d51f4b646578f
- Source dataset
- uspto-grants-1998_10
- Patent number
- US05827638
Reaction notes
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