Acetyl chloride → Methyl 3-(3-bromophenyl)prop-2-enoate

HRID 400227

Reaction equation

HRID 400227 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[CH:5]=[CH:6][C:7]([OH:9])=[O:8].[C:13](Cl)(=O)C>CO>[Br:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[CH:5]=[CH:6][C:7]([O:9][CH3:13])=[O:8]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 362513-(3-Bromophenyl)acrylic acid

Product 1

HCID 610698Methyl 3-(3-bromophenyl)prop-2-enoate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent3×

Procedure

To a solution of 50.0 g (220 mmol, Aldrich) of 3-bromocinnamic acid in 1 L sieve-dried methanol (Burdick & Jackson), stirred at 0° C., was added dropwise a solution of acidic methanol (prepared by the addition of 2.5 mL acetyl chloride to 250 mL methanol). The reaction

Workup

  1. customThe reaction

Sources & evidence

ORD record
ord-f8d184a5c3014a92bc4fb77c554723dc
Source dataset
uspto-grants-1998_10
Patent number
US05827868

Linked notes

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