Water → HCID 178497263, compound

HRID 400485

Reaction equation

HRID 400485 reaction equation
C(O)(=O)C.[NH2:5][NH2:6].[CH3:7][O:8][C:9](=[O:21])[C:10](=O)[CH2:11][C:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.O>C(O)(=O)C>[CH3:7][O:8][C:9]([C:10]1[CH:11]=[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[NH:6][N:5]=1)=[O:21]

Participants

5

Reactant 3

HCID 962WaterHCID 165591Hydrazine, acetate (1:1)HCID 308117Methyl 2,4-dioxo-4-phenylbutanoate

Product 1

HCID 178497263HCID 178497263, compoundYield 66.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

983 mg hydrazine acetate was added to 2 g 2,4-Dioxo-4-phenyl-butyric acid methyl ester in 10 mL concentrated acetic acid. The mixture was stirred over night at RT. Then water was added. The precipitate was filtered, stirred with diisopropylether and again filtered to give 1.3 g desired product. Rt: 1.39 min (method O), (M+H)+: 203

Workup

  1. filtrationThe precipitate was filtered
  2. stirringstirred with diisopropylether
  3. filtrationagain filtered

Sources & evidence

ORD record
ord-8ffbecc03032464c90cc429146c8e351
Source dataset
uspto-grants-2014_06
Patent number
US08741892B2

Linked notes

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