Isovanillin → 4-Methoxy-3-(2-methoxyethoxy)benzaldehyde
Reaction equation
OC1[C:9]([O:10][CH2:11]CC)=[CH:8]C(C=O)=CC=1[N+]([O-])=O.[OH:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH:21]=[O:22]>>[CH3:27][O:26][C:25]1[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][C:18]=1[O:17][CH2:8][CH2:9][O:10][CH3:11]Participants
3
Procedure
Followed the procedure described in Step 2 of Intermediate 65 starting from 3-hydroxy-4-methoxybenzaldehyde, isolated 2.4 g, yield 89%.
Workup
- customisolated 2.4 g, yield 89%
Sources & evidence
- ORD record
- ord-aded3f5c37f24d268f15923990a7fd19
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08741915B2
Reaction notes
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