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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40164Generated: October 26, 2026

2-Bromothiazole → N-(3,4-Difluorobenzyl)-2-isopropyl-1-(oxazol-2-ylmethyl)-6-(thiazol-2-yloxy)-1H-indole-3-carboxamide

https://huagongshe.com/reaction/40164

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-BromothiazoleHCID 76430—
ReactantN-(3,4-difluorobenzyl)-6-hydroxy-2-isopropyl-1-(oxazol-2-ylmethyl)-1H-indole-3-carboxamideHCID 59762311—
SolventDimethyl SulfoxideHCID 679—
ProductN-(3,4-Difluorobenzyl)-2-isopropyl-1-(oxazol-2-ylmethyl)-6-(thiazol-2-yloxy)-1H-indole-3-carboxamideHCID 59762429—

Reaction Steps

The title compound was prepared from N-(3,4-difluorobenzyl)-6-hydroxy-2-isopropyl-1-(oxazol-2-ylmethyl)-1H-indole-3-carboxamide (Compound 210), 2-bromothiazole and DMSO with heating following General Procedure N.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08524917B2
Source datasetuspto-grants-2013_09
ORD IDord-5f54decd916a40c8b9a572bd1248c22c
Source noteuspto-grants-2013_09